Search results for "Anti cancer"

showing 3 items of 3 documents

Is Resveratrol a Cancer Immunomodulatory Molecule?

2018

0301 basic medicinePharmacologyOpinionmelinjoChemistrymedicine.medical_treatmentlcsh:RM1-950CancerImmunotherapyResveratrolresveratrolmedicine.diseaseNKG2DNKG2D03 medical and health scienceschemistry.chemical_compound030104 developmental biology0302 clinical medicinelcsh:Therapeutics. Pharmacology030220 oncology & carcinogenesismedicineCancer researchPharmacology (medical)immunotherapyanti cancerFrontiers in Pharmacology
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Anti-cancer activity of di- and tri-organotin(IV) compounds with D-(+)-Galacturonic acid on human tumor cells

2018

Abstract We have compared the anti-proliferative activity in vitro, of R2SnGala (1-3) [R = Me, n-Bu, Ph] and novel R3SnGala (4, 5) [R = Me, n-Bu] with D-(+)-Galacturonic acid [HGala; Galaq-, q = (2) and (1) for R2SnGala and R3SnGala, respectively] compounds, towards human tumor cell lines of intestinal carcinoma (HCT-116) and breast adenocarcinoma (MCF-7). The new synthesized 4 and 5 compounds were characterized, in solution, by 1H, 13C and 119Sn NMR, that showed that HGala acts as monoanionic moiety and evidenced the dynamic behavior of the compounds, due to inter-conversions involving the anomeric carbon atom of the ligand. Cell viability, apoptosis induction and cell cycle distribution w…

Anti cancerCarbohydrateCell SurvivalHCT-116Antineoplastic AgentsApoptosisBreast NeoplasmsOrganotin(IV)Adenocarcinoma010402 general chemistry01 natural sciencesBiochemistryFlow cytometryInorganic ChemistryOrganotin(IV); D-(+)-Galacturonic acid; NMR; Anti cancer; HCT-116; MCF-7Intestinal NeoplasmsmedicineOrganotin CompoundsCytotoxic T cellHumansViability assayCytotoxicityD-(+)-Galacturonic acidmedicine.diagnostic_testAnti-proliferative010405 organic chemistryCell growthChemistryHexuronic AcidsMCF-7 .Cell cycleHCT116 CellsMolecular biologyNMR0104 chemical sciencesCell cultureApoptosisSettore CHIM/03 - Chimica Generale E InorganicaMCF-7 CellsMCF-7Caco-2 Cells
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Chemotherapy cardiotoxicity: cardioprotective drugs and early identification of cardiac dysfunction.

2016

Background: Chemotherapy cardiotoxicity is an emerging problem and it is very important to prevent cardiac dysfunction caused by anticancer drugs. The aim of this study was to assess the alterations of the cardiac function induced by chemotherapy in a follow-up of 2 years and to evaluate the cardioprotective role of angiotensin-converting enzyme inhibitors (ACEIs) in the prevention of cardiac dysfunction. Methods: A prospective study was carried out using patients with breast cancer (85 women; median age 57W12years) and other inclusion and exclusion criteria. On the basis of treatment, patients were divided into six groups: fluorouracil-epirubicincyclophosphamide, FEC (group A); FEC and tra…

Cardiac function curveAdultmedicine.medical_specialtyCardiotonic Agentsmedicine.medical_treatmentAngiotensin-Converting Enzyme InhibitorsBreast Neoplasms030204 cardiovascular system & hematologyBioinformaticsCardiac dysfunctionAngiotensin-converting enzyme inhibitor; Cardiotoxicity; Chemotherapy; Prevention; Tissue Doppler imaging; Adult; Aged; Aged 80 and over; Angiotensin-Converting Enzyme Inhibitors; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cardiotonic Agents; Cardiotoxicity; Early Diagnosis; Echocardiography Doppler; Female; Follow-Up Studies; Humans; Middle Aged; Prospective Studies03 medical and health sciencesTissue Doppler imaging0302 clinical medicinecardiac toxicity anti cancer drugs cardiac dysfunctionInternal medicineAntineoplastic Combined Chemotherapy Protocols80 and overMedicineChemotherapyHumansProspective StudiesAgedAged 80 and overCardiotoxicityChemotherapybusiness.industryPreventionFollow up studiesDopplerGeneral MedicineMiddle AgedCardiotoxicityEchocardiography DopplerClinical trialEarly DiagnosisAngiotensin-converting enzyme inhibitorEchocardiography030220 oncology & carcinogenesiscardiovascular systemCardiologyFemaleCardiology and Cardiovascular MedicinebusinessFollow-Up StudiesJournal of cardiovascular medicine (Hagerstown, Md.)
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